The application of Botulinum toxin is one of the treatments offered better results for removing wrinkles or rhytidosis treatment. This form of botulinum toxin, after infiltration with extra fine needle into the muscle under the skin of the area to be treated, for relaxation inhibits muscle movement. This effect is intended wrinkles disappear and therefore provide a more youthful skin. Temporary lasts between 3 to 6 months, during which must be renewed after the dose. Rarely have cases of side effects such as allergic reactions, facial rigidity, or nausea.